Baylor University Medical Center Proceedings · 2000 · 131 citations · 15 references
Acute PainPain MedicinePerioperative MedicineSurgeryAnalgesiaImmune SystemPain ManagementAnalgesicsHealth SciencesRegional AnesthesiaPostoperative Pain ManagementPerioperative PainNeuropharmacologyPreoperative PainCare.the FailureLocal Anesthetic Pharmacology.The AdvantagesPain ResearchPatient SafetyAnesthesiaMedicineAnesthesiology
ffective postoperative pain control is an essential compo-nent of the care of the surgical patient. Inadequate paincontrol, apart from being inhumane, may result in in-creased morbidity or mortality (1, 2). Evidence suggests that sur-gery suppresses the immune system and that this suppression isproportionate to the invasiveness of the surgery (3, 4). Goodanalgesia can reduce this deleterious effect. Data available indi-cate that afferent neural blockade with local anesthetics is themost effective analgesic technique. Next in order of effectivenessare high-dose opioids, epidural opioids and clonidine, patient-controlled opioid therapy, and nonsteroidal anti-inflammatoryagents (5).The advantages of effective postoperative pain managementinclude patient comfort and therefore satisfaction, earlier mo-bilization, fewer pulmonary and cardiac complications, a reducedrisk of deep vein thrombosis, faster recovery with less likelihoodof the development of neuropathic pain, and reduced cost of care.The failure to provide good postoperative analgesia is multi-factorial. Insufficient education, fear of complications associatedwith analgesic drugs, poor pain assessment, and inadequate staff-ing are among its causes.
15
Controlled Sedation with Alphaxalone-Alphadolone
Michael A. E. Ramsay, T.M. Savege, B. R. Simpson et al. · BMJ · 1974 · 2.9K citations · Full text
Sedative, Amnestic, and Analgesic Properties of Small-Dose Dexmedetomidine Infusions
Judith Hall, Toni D. Uhrich, Jill A. Barney et al. · Anesthesia & Analgesia · 2000 · 1.1K citations
Epidural Anesthesia and Analgesia in High-risk Surgical Patients
Mark P. Yeager, D. David Glass, Raymond K. Neff et al. · Anesthesiology · 1987 · 996 citations · Full text
Health Sciences, Controlled Clinical Trial, Pain Medicine +15
Acute Pain after Thoracic Surgery Predicts Long-Term Post-Thoracotomy Pain
Joel Katz, Marla Jackson, Brian P. Kavanagh et al. · Clinical Journal of Pain · 1996 · 923 citations