The Effect of Microelements Supplementation on β-oxidation Activity in Healthy and Type 1 Diabetic Rats

Abstract

Diabetes mellitus type 1 disease changes the activity of fatty acid degradation as compared to healthy animals. Supplementation in vitro with microelements chromium Cr3+ and selenium Se4+ and Se2- in non-toxic ([96.15 pmol (5 ppm) for chromium and 6.33 micromol (0.5 ppm) for selenium] concentrations strongly stimulates the activity of this process in diabetic rats. In healthy animals only chromium Cr3+ in concentration of 96.15 micromol (5 ppm) stimulated beta-oxidation activity in lymphocytes. It may indicate the beneficial effect of supplementation of the diet with microelements, chromium Cr3 and selenium Se4+ or Se2- at concentrations as low as 100 micromol for chromium and 6 micromol for selenium, respectively.