Concepedia

Sodium butyrate, a histone deacetylase inhibitor, regulates Lymphangiogenic factors in oral cancer cell line HSC-3.

Takashi Yamamura, Naoyuki Matsumoto, Yasuyoshi Matsue, Michisato Okudera, Youichi Nishikawa, Yoshimitsu Abiko, Kazuo Komiyama

PubMed · 2014 · 21 citations · 38 references

Abstract

SB inhibits expression of lymphangiogenic factors in HSC-3 cells. Within the limitations of the present study, SB may have potential as an anti-metastatic pro-drug for oral cancer.

References

38

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

Noel Weidner, Joseph P. Semple, William R. Welch et al. · New England Journal of Medicine · 1991 · 5.7K citations

Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

Marc G. Achen, Michael Jeltsch, Eola Kukk et al. · Proceedings of the National Academy of Sciences · 1998 · 1.2K citations · Full text

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

Myoung Sook Kim, Ho Jeong Kwon, You Mie Lee et al. · Nature Medicine · 2001 · 727 citations

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VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis

Satoshi Hirakawa, Shohta Kodama, Rainer Kunstfeld et al. · The Journal of Experimental Medicine · 2005 · 718 citations · Full text

Regulation and Destabilization of HIF-1α by ARD1-Mediated Acetylation

Joo-Won Jeong, Moon-Kyoung Bae, Mee-Young Ahn et al. · Cell · 2002 · 712 citations · Full text

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