Molecular Determinants of Diltiazem Block in Domains IIIS6 and IVS6 of L-type Ca²⁺Channels

Rapid and efficient site-specific mutagenesis without phenotypic selection.

Thomas A. Kunkel · Proceedings of the National Academy of Sciences · 1985 · 7.3K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +15

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

Robert M. Horton, Henry D. Hunt, Steffan N. Ho et al. · Gene · 1989 · 3.1K citations

Life Sciences, Genetics, Molecular Biology +10

Primary structure of the receptor for calcium channel blockers from skeletal muscle

Tsutomu Tanabe, Hiroshi Takeshima, Atsushi Mikami et al. · Nature · 1987 · 1.4K citations

Life Sciences, Biochemistry, Physiology +16

Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells

K. S. Lee, Richard W. Tsien · Nature · 1983 · 855 citations

Medicine, Cardiology, Pharmacology +12

Sequence and Expression of mRNAs Encoding the α ₁ and α ₂ Subunits of a DHP-Sensitive Calcium Channel

S.B. Ellis, Mark E. Williams, Nancy R. Ways et al. · Science · 1988 · 579 citations

Life Sciences, Genetics, Molecular Biology +17