IDOL, inducible degrader of low-density lipoprotein receptor, serves as a potential therapeutic target for dyslipidemia

Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts

Joseph L. Goldstein, Michael S. Brown · Journal of Biological Chemistry · 1974 · 1.5K citations · Full text

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LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

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Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity

Michael S. Brown, Joseph L. Goldstein · Proceedings of the National Academy of Sciences · 1974 · 597 citations · Full text

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Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial

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Metabolic Syndrome, Oxysterol, Biochemistry +9

National Lipid Association recommendations for patient-centered management of dyslipidemia: Part 1 – executive summary

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