Concepedia

Predicting the Effect of CYP3A Inducers on the Pharmacokinetics of Substrate Drugs Using Physiologically Based Pharmacokinetic (PBPK) Modeling: An Analysis of PBPK Submissions to the US FDA

Christian Wagner, Yuzhuo Pan, Vicky Hsu, Vikram Sinha, Ping Zhao

Clinical Pharmacokinetics · 2015 · 93 citations · 6 references

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Concepts

References

6

Critique of the Two-Fold Measure of Prediction Success for Ratios: Application for the Assessment of Drug-Drug Interactions

Eleanor J. Guest, Leon Aarons, J. Brian Houston et al. · Drug Metabolism and Disposition · 2010 · 191 citations

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Predicting the Effect of Cytochrome P450 Inhibitors on Substrate Drugs: Analysis of Physiologically Based Pharmacokinetic Modeling Submissions to the US Food and Drug Administration

Christian Wagner, Yuzhuo Pan, Vicky Hsu et al. · Clinical Pharmacokinetics · 2014 · 145 citations

, , +17

Evaluation of Various Static and Dynamic Modeling Methods to Predict Clinical CYP3A Induction Using In Vitro CYP3A4 mRNA Induction Data

Heidi J. Einolf, L Chen, Odette A. Fahmi et al. · Clinical Pharmacology & Therapeutics · 2013 · 91 citations

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Physiologically based pharmacokinetic modeling of CYP3A4 induction by rifampicin in human: Influence of time between substrate and inducer administration

Guillaume Baneyx, Neil Parrott, Christophe Meille et al. · European Journal of Pharmaceutical Sciences · 2014 · 80 citations

, , +13

PBPK Model Describes the Effects of Comedication and Genetic Polymorphism on Systemic Exposure of Drugs That Undergo Multiple Clearance Pathways

Manuela de Lima Toccafondo Vieira, Myeong‐Jin Kim, S Apparaju et al. · Clinical Pharmacology & Therapeutics · 2014 · 65 citations

, , +15