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BACE-1 inhibitory activities of new substituted phenyl-piperazine coupled to various heterocycles: Chromene, coumarin and quinoline

Cédrik Garino, Nicolas Pietrancosta, Younès Laras, Vincent Moret, Amandine Rolland, Gilles Quéléver, Jean‐Louis Kraus

Bioorganic & Medicinal Chemistry Letters · 2006 · 54 citations · 12 references

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12

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

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Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization

J. M. Orgogozo, S. Gilman, Jean‐François Dartigues et al. · Neurology · 2003 · 1.3K citations

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Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

Gwendolyn T. Wong, Denise Manfra, Frederique M. Poulet et al. · Journal of Biological Chemistry · 2004 · 716 citations · Full text

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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

Steven L. Roberds · Human Molecular Genetics · 2001 · 703 citations

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