Concepedia

Optimization of the 4-aryl group of 4-aryl-pyridine glucagon antagonists: development of an efficient, alternative synthesis

Roger A. Smith, Donald L. Hertzog, Martin H. Osterhout, Gaétan Ladouceur, Mary Korpusik, Mark A. Bobko, Jerome Jones, Kathleen M. Phelan, Romulo H. Romero, Thomas Hundertmark,

Bioorganic & Medicinal Chemistry Letters · 2002 · 16 citations · 11 references

Open access

Concepts

Combinatorial ChemistryMedicinal Chemistry4-Aryl GroupNatural SciencesDrug DiscoveryDiversity-oriented SynthesisMedicineAlternative SynthesisOrganic ChemistryStereoselective SynthesisPharmacologyPharmaceutical ChemistrySynthetic ChemistryBiomolecular Engineering4-Aryl-pyridine Glucagon Antagonists

References

11

The Rising Global Burden of Diabetes and its Complications: Estimates and Projections to the Year 2010

Angelyne Amos, Daniel J. McCarty, Paul Zimmet · Diabetic Medicine · 1997 · 1.7K citations

Year 2010, Non-communicable Disease, Obesity +18

Utilization of operational schemes for analog synthesis in drug design

John G. Topliss · Journal of Medicinal Chemistry · 1972 · 452 citations

Engineering, Quantitative Pharmacology, Altmetric Attention Score +21

Hantzsch-type dihydropyridine hypotensive agents

Bernard Loev, M. M. GOODMAN, Kenneth M. Snader et al. · Journal of Medicinal Chemistry · 1974 · 344 citations

Engineering, Altmetric Attention Score, Bibliometrics +20

Enantioselective synthesis of binaphthyls via nucleophilic aromatic substitution on chiral oxazolines

A. I. MEYERS, K. Lutomski · Journal of the American Chemical Society · 1982 · 141 citations

Chiral Oxazolinesa, Chemical Engineering, Chiral Oxazolines +15

Rapid, High-Yield Oxidation of Hantzsch-Type 1,4-Dihydropyridines with Ceric Ammonium Nitrate

Jürg R. Pfister · Synthesis · 1990 · 137 citations

Hantzsch-type 1,4-Dihydropyridines, Chemical Engineering, Derivative (Chemistry) +8