First synthesis of indirubin N-glycosides (red sugars)

A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization.

Satoshi Ōmura, YUZURU IWAI, Atsushi Hirano et al. · The Journal of Antibiotics · 1977 · 672 citations · Full text

Life Sciences, Biochemistry, Microbiology +10

Structural Basis for the Synthesis of Indirubins as Potent and Selective Inhibitors of Glycogen Synthase Kinase-3 and Cyclin-Dependent Kinases

Panagiotis Polychronopoulos, Prokopios Magiatis, Alexios‐Léandros Skaltsounis et al. · Journal of Medicinal Chemistry · 2004 · 376 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives

Yoshinori Yamashita, Noboru Fujii, Chikara Murakata et al. · Biochemistry · 1992 · 146 citations

Medicine, Cancer Biology, Molecular Biology +11

Staurosporine and <i>ent</i>-Staurosporine:  The First Total Syntheses, Prospects for a Regioselective Approach, and Activity Profiles¹

J. T. Link, Subharekha Raghavan, Michel Gallant et al. · Journal of the American Chemical Society · 1996 · 133 citations

Life Sciences, Biochemistry, Chemistry +17

Synthesis and structure–activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities

Myoung Ju Moon, Sang Kook Lee, Jong‐Won Lee et al. · Bioorganic & Medicinal Chemistry · 2005 · 133 citations

Medicine, Medicinal Chemistry, Pharmacology +10