Chikara Murakata

K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

Hiroshi Kase, Kazuyuki Iwahashi, Satoshi Nakanishi et al. · Biochemical and Biophysical Research Communications · 1987 · 942 citations

Protein Kinase C, Biochemistry, Medicine +8

Rescue of Hearing, Auditory Hair Cells, and Neurons by CEP-1347/KT7515, an Inhibitor of c-Jun N-Terminal Kinase Activation

Ulla Pirvola, Liang Xing-Qun, Jussi Virkkala et al. · Journal of Neuroscience · 2000 · 308 citations · Full text

Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives

Yoshinori Yamashita, Noboru Fujii, Chikara Murakata et al. · Biochemistry · 1992 · 146 citations

KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.

Shiro Soga, LM Neckers, T W Schulte et al. · PubMed · 1999 · 137 citations

Hsp90 Binding, Hsp90 Family Proteins, Selective Depletion +16

Sustained in vivo regression of Dunning H rat prostate cancers treated with combinations of androgen ablation and Trk tyrosine kinase inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555).

Daniel J. George, Craig A. Dionne, Jacques Jani et al. · PubMed · 1999 · 126 citations

Urology, Androgen Ablation, Chemoprevention Strategy +14