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New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors

Bernard Barlaam, Mike Fennell, Hervé Germain, Tim Green, Laurent Hennequin, Rémy Morgentin, Annie Olivier, Patrick A. Plé, Michel Vautier, Gerard Costello

Bioorganic & Medicinal Chemistry Letters · 2005 · 28 citations · 16 references

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References

16

Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer.

Mark S. Talamonti, Mark S. Roh, S. Curley et al. · Journal of Clinical Investigation · 1993 · 397 citations · Full text

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Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling

Egle Avizienyte, Anne W. Wyke, Robert J. Jones et al. · Nature Cell Biology · 2002 · 354 citations

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Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.

Carolyn Lowe, Toshiyuki Yoneda, Brendan F. Boyce et al. · Proceedings of the National Academy of Sciences · 1993 · 336 citations

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The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

Valerie J. Fincham · The EMBO Journal · 1998 · 288 citations · Full text

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Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis.

Christine A. Cartwright, A I Meisler, Walter Eckhart · Proceedings of the National Academy of Sciences · 1990 · 278 citations

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