Gerard Costello

<i>N</i>-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2<i>H</i>-pyran-4-yloxy)quinazolin-4-amine, a Novel, Highly Selective, Orally Available, Dual-Specific c-Src/Abl Kinase Inhibitor

Laurent Hennequin, J M Allen, J. Breed et al. · Journal of Medicinal Chemistry · 2006 · 358 citations · Full text

Drug Target, Pharmacotherapy, Pharmaceutical Chemistry +16

Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

Tim P. Green, Mike Fennell, Robin Whittaker et al. · Molecular Oncology · 2009 · 254 citations · Full text

Discovery of a New Class of Anilinoquinazoline Inhibitors with High Affinity and Specificity for the Tyrosine Kinase Domain of c-Src

Patrick A. Plé, Tim P. Green, Laurent Hennequin et al. · Journal of Medicinal Chemistry · 2004 · 167 citations · Full text

Drug Target, Anilinoquinazoline Inhibitors, Pharmacotherapy +18

2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid .kappa. agonists

Gerard Costello, Roger James, John S. Shaw et al. · Journal of Medicinal Chemistry · 1991 · 75 citations · Full text

Combinatorial Chemistry, Organic Chemistry, Pharmacotherapy +19

A novel series of potent and selective agonists at the opioid κ-receptor

Gerard Costello, Brain G. Main, Jeffrey J. Barlow et al. · European Journal of Pharmacology · 1988 · 70 citations

Molecular Pharmacology, Novel Series, Opioid κ-Receptor +10