<i>N</i>-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2<i>H</i>-pyran-4-yloxy)quinazolin-4-amine, a Novel, Highly Selective, Orally Available, Dual-Specific c-Src/Abl Kinase Inhibitor

Laurent Hennequin, J M Allen, J. Breed, +11

Journal of Medicinal Chemistry

Drug TargetPharmacotherapyPharmaceutical ChemistryMolecular PharmacologyMedicinal Chemistry +14

Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

Tim P. Green, Mike Fennell, Robin Whittaker, +17

Molecular Oncology

Discovery of a New Class of Anilinoquinazoline Inhibitors with High Affinity and Specificity for the Tyrosine Kinase Domain of c-Src

Patrick A. Plé, Tim P. Green, Laurent Hennequin, +5

Journal of Medicinal Chemistry

Drug TargetAnilinoquinazoline InhibitorsPharmacotherapyChemical BiologyPharmaceutical Chemistry +16

2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid .kappa. agonists

Gerard Costello, Roger James, John S. Shaw, +2

Journal of Medicinal Chemistry

Combinatorial ChemistryOrganic ChemistryPharmacotherapyHeterocycle ChemistryExperimental Pharmacology +17

A novel series of potent and selective agonists at the opioid κ-receptor

Gerard Costello, Brain G. Main, Jeffrey J. Barlow, +2

European Journal of Pharmacology

Molecular PharmacologyNovel SeriesOpioid κ-ReceptorMedicineDrug Discovery +8

A Total Synthesis of (±)-Zoapatanol and Demethyl-ORF13811

Philip Kocieński, Christopher J. Love, Whitby Richard J, +2

Tetrahedron

PharmacologyTotal SynthesisOrganic ChemistryNatural Product SynthesisSynthetic Chemistry

Structure activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]acetamides: a novel series of potent and selective .kappa.-opioid agonists

Jeffrey J. Barlow, Thomas P. Blackburn, Gerard Costello, +6

Journal of Medicinal Chemistry

Combinatorial ChemistryBioorganic ChemistryOrganic ChemistryPharmacotherapyChemistry +20

Poly(dipeptamidinium)‐Salze: Definition und Methoden zur präparativen Herstellung

Heinz E. Moser, Anton Fliri, Arthur Steiger, +3

Helvetica Chimica Acta

Bioorganic ChemistryEngineeringResponsive PolymersMolecular BiologyChemical Biology +17

New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors

Bernard Barlaam, Mike Fennell, Hervé Germain, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryHeterocyclicBiochemistryNatural SciencesMedicine +5

A synthetic approach to zoapatanol and related bicyclic analogues

Richard J. Whitby, Clive Yeates, Philip Kocieński, +1

Journal of the Chemical Society Chemical Communications

Medicinal ChemistryOxepane Ring SystemHeterocyclicBiochemistryNatural Sciences +12