Hervé Germain

Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors

Frédéric Jung, Georges Pasquet, Christine Lambert‐van der Brempt et al. · Journal of Medicinal Chemistry · 2006 · 92 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers

Bernard Barlaam, Sabina Cosulich, Bénédicte Delouvrié et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 35 citations

Medicine, Medicinal Chemistry, Pharmacology +8

New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors

Bernard Barlaam, Mike Fennell, Hervé Germain et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 28 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

A versatile route to 3-(pyrimidin-4-yl)-imidazo[1,2-a]pyridines and 3-(pyrimidin-4-yl)-pyrazolo[1,5-a]pyridines

Richard Ducray, Pascal Boutron, Myriam Didelot et al. · Tetrahedron Letters · 2010 · 19 citations

Pharmacy, Chemistry, Medicinal Chemistry +8

A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Bernard Barlaam, Peter Ballard, Robert H. Bradbury et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 18 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14