The design and synthesis of sulfonamides as caspase-1 inhibitors

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

Nancy A. Thornberry, Herbert G. Bull, Jimmy Calaycay et al. · Nature · 1992 · 2.6K citations

Life Sciences, Immunology, Molecular Biology +12

Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer

Nigel P.C. Walker, Robert V. Talanian, Kenneth D. Brady et al. · Cell · 1994 · 570 citations

Life Sciences, Biochemistry, Molecular Biology +14

Lipopolysaccharide Activates Caspase-1 (Interleukin-1–Converting Enzyme) in Cultured Monocytic and Endothelial Cells

Ralf R. Schumann, Claus Belka, Dirk Reuter et al. · Blood · 1998 · 157 citations · Full text

Life Sciences, Cell Biology, Immunology +16

Pro- and anti-inflammatory roles of interleukin-1 in recurrence of bacterial cell wall-induced arthritis in rats

John H. Schwab, S K Anderle, R R Brown et al. · Infection and Immunity · 1991 · 151 citations · Full text

Medicine, Immunology, Pharmacology +17

Inhibition of interleukin-1-induced synovitis and articular cartilage proteoglycan loss in the rabbit knee by recombinant human interleukin-1 receptor antagonist

Brian E. Henderson, Robert C. Thompson, Tim Hardingham et al. · Cytokine · 1991 · 115 citations

Medicine, Immunology, Orthopedic Surgery +17