Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes

Robert F. Bruns, James H. Fergus, Edward W. Badger, +5

Naunyn-Schmiedeberg s Archives of Pharmacology

BiochemistryNeurophysiologyMedicineNeuropeptide ReceptorNeuropharmacology +7

An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.

Kevin Wang, Rathna Nath, Avigail Posner, +15

Proceedings of the National Academy of Sciences

Inhibitory ActivityMedicinal ChemistryProtein FunctionBiochemistryNatural Sciences +12

2-Amino-4<i>H</i>-3,1-benzoxazin-4-ones as Inhibitors of C1r Serine Protease

Sheryl J. Hays, Bradley W. Caprathe, John L. Gilmore, +10

Journal of Medicinal Chemistry

Combinatorial ChemistryComplement Enzyme C1rMedicinal ChemistryC1r Serine ProteaseBioorganic Chemistry +12

Substituted 2-Benzothiazolamines as Sodium Flux Inhibitors: Quantitative Structure-Activity Relationships and Anticonvulsant Activity

Sheryl J. Hays, Michael J. Rice, Daniel F. Ortwine, +6

Journal of Pharmaceutical Sciences

Quantitative Structure-activity RelationshipsMedicineDrug DiscoveryMechanism Of ActionPharmacological Agent +7

PD 115,199: An antagonist ligand for adenosine A2 receptors

Robert F. Bruns, James H. Fergus, Edward W. Badger, +3

Naunyn-Schmiedeberg s Archives of Pharmacology

Signal TransductionG Protein-coupled ReceptorAdenosine A2 ReceptorsMedicineFunctional Selectivity +3

The design and synthesis of sulfonamides as caspase-1 inhibitors

William G. Harter, Hans Albrect, Kenneth D. Brady, +7

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBioorganic ChemistryCaspase-1 InhibitorsMedicine +5

Synthesis of cis-4-(phosphonooxy)-2-piperidinecarboxylic acid, an N-methyl-D-aspartate antagonist

Sheryl J. Hays, Thomas C. Malone, Graham Johnson

The Journal of Organic Chemistry

Pharmaceutical ScienceBioorganic ChemistryAltmetric Attention ScoreSecondary MetabolitePharmacotherapy +14

Synthesis and evaluation of 2-aryl-4H-3,1-benzoxazin-4-ones as C1r serine protease inhibitors

John L. Gilmore, Sheryl J. Hays, Bradley W. Caprathe, +4

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryNatural SciencesMedicineDrug Development +4

New and versatile approaches to the synthesis of CPP-related competitive NMDA antagonists. Preliminary structure activity relationships and pharmacological evaluation

Sheryl J. Hays, Christopher F. Bigge, Perry M. Novak, +6

Journal of Medicinal Chemistry

Binding AffinityVersatile ApproachesPharmacotherapyChemical BiologyNmda Ligands +17

Structure-activity relationship study of the inhibition of adrenal cortical 11.beta.-hydroxylase by new metyrapone analogs

Sheryl J. Hays, Michael C. Tobes, David L. Gildersleeve, +2

Journal of Medicinal Chemistry