Isoxazoles from 1,1-disubstituted bromoalkenes

Frontier molecular orbital theory of cycloaddition reactions

K. N. Houk · Accounts of Chemical Research · 1975 · 795 citations

Natural Sciences, Chemistry, Chemical Kinetics +8

Origin of reactivity, regioselectivity, and periselectivity in 1,3-dipolar cycloadditions

K. N. Houk, Joyner Sims, Charles R. Watts et al. · Journal of the American Chemical Society · 1973 · 718 citations

Natural Sciences, Chemistry, Inorganic Chemistry +9

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib:  A Potent and Selective Inhibitor of COX-2

John J. Talley, David Brown, Jeffery S. Carter et al. · Journal of Medicinal Chemistry · 2000 · 643 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8

Frontier molecular orbitals of 1,3 dipoles and dipolarophiles

K. N. Houk, Joyner. Sims, R. E. JUN. DUKE et al. · Journal of the American Chemical Society · 1973 · 571 citations

Natural Sciences, Chemistry, Drug Design +7

Heterocyclic and Phenyl Double-Bond-Locked Combretastatin Analogues Possessing Potent Apoptosis-Inducing Activity in HL60 and in MDR Cell Lines

Daniele Simoni, Giuseppina Grisolia, Giuseppe Giannini et al. · Journal of Medicinal Chemistry · 2005 · 148 citations

Medicine, Medicinal Chemistry, Pharmacology +15