Structural variations of piritrexim, a lipophilic inhibitor of human dihydrofolate reductase: synthesis, antitumor activity and molecular modeling investigations

The Protein Data Bank

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Life Sciences, Biochemistry, Bioinformatics +10

Oxidation of long-chain and related alcohols to carbonyls by dimethyl sulfoxide "activated" by oxalyl chloride

Anthony J. Mancuso, Shui‐Lung Huang, Daniel Swern · The Journal of Organic Chemistry · 1978 · 1.6K citations

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QXP: Powerful, rapid computer algorithms for structure-based drug design

Colin McMartin, Regine S. Bohacek · Journal of Computer-Aided Molecular Design · 1997 · 512 citations

Pharmacy, Bioinformatics, Medicinal Chemistry +12

Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine

E. M. GRIVSKY, Shuliang Lee, Carl W. Sigel et al. · Journal of Medicinal Chemistry · 1980 · 359 citations

Medicine, Medicinal Chemistry, Pharmacology +8

High-Affinity Inhibitors of Dihydrofolate Reductase:  Antimicrobial and Anticancer Activities of 7,8-Dialkyl-1,3-diaminopyrrolo[3,2-<i>f</i>]quinazolines with Small Molecular Size

Lee F. Kuyper, David P. Baccanari, Michael L. Jones et al. · Journal of Medicinal Chemistry · 1996 · 107 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15