Concepedia

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. III: synthesis, antiviral and pharmacokinetic profiles of symmetrical heteroaryl carboxamides

Stuart W. McCombie, Jayaram R. Tagat, Susan F. Vice, Sue‐Ing Lin, Ruo W. Steensma, Anandan Palani, Bernard R. Neustadt, Bahige M. Baroudy, Julie Strizki, M. Endres,

Bioorganic & Medicinal Chemistry Letters · 2003 · 52 citations · 16 references

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16

Vpr Is Required for Efficient Replication of Human Immunodeficiency Virus Type-1 in Mononuclear Phagocytes

Ruth I. Connor, Benjamin K. Chen, Sunny Choe et al. · Virology · 1995 · 1.3K citations · Full text

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SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection <i>in vitro</i> and <i>in vivo</i>

Julie Strizki, Serena Xu, Nicole Wagner et al. · Proceedings of the National Academy of Sciences · 2001 · 300 citations · Full text

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Discovery of Novel, Potent, and Selective Small-Molecule CCR5 Antagonists as Anti-HIV-1 Agents:  Synthesis and Biological Evaluation of Anilide Derivatives with a Quaternary Ammonium Moiety

Mitsuru Shiraishi, Yoshio Aramaki, Masaki Seto et al. · Journal of Medicinal Chemistry · 2000 · 185 citations · Full text

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Atropisomeric Amides as Chiral Ligands:  Using (−)-Sparteine-Directed Enantioselective Silylation to Control the Conformation of a Stereogenic Axis

Jonathan Clayden, Paul D. Johnson, Jennifer H. Pink et al. · The Journal of Organic Chemistry · 2000 · 138 citations

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Novel Low Molecular Weight Spirodiketopiperazine Derivatives Potently Inhibit R5 HIV-1 Infection through Their Antagonistic Effects on CCR5

Kenji Maeda, Kazuhisa Yoshimura, Shiro Shibayama et al. · Journal of Biological Chemistry · 2001 · 126 citations · Full text

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