Concepedia

N -acetylcysteine amide, a promising antidote for acetaminophen toxicity

Ahdab N. Khayyat, Shakila Tobwala, Marcia L. Hart, Nuran Erçal

Toxicology Letters · 2015 · 65 citations · 65 references

DOI

Concepts

References

65

Acetaminophen‐induced acute liver failure

Anne M. Larson, Julie Polson, Robert J. Fontana et al. · Hepatology · 2005 · 1.9K citations

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ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. I. ROLE OF DRUG METABOLISM

John R. Mitchell, David J. Jollow, William Z. Potter et al. · Journal of Pharmacology and Experimental Therapeutics · 1973 · 1.5K citations

, , +17

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.

David C. Dahlin, Gerald T. Miwa, Albert Lu et al. · Proceedings of the National Academy of Sciences · 1984 · 1.1K citations

, , +16

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

Mitchell R. McGill, Matthew R. Sharpe, C. David Williams et al. · Journal of Clinical Investigation · 2012 · 763 citations · Full text

, , +17

Acute liver necrosis following overdose of paracetamol.

Diana Davidson, W. N. Eastham · BMJ · 1966 · 534 citations · Full text

, , +15