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Publication | Open Access

Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia

DOIFull Paper Access

90

Citations

33

References

2011

Year

Jacqueline M. Tromp, Christian R. Geest, Esther C.W. Breij, Judith A. Elias, Jacoline van Laar, Dieuwertje M. Luijks, Arnon P. Kater, Tim Beaumont, Marinus H. J. van Oers, Eric Eldering
Clinical Cancer Research

Abstract

Thus, the Noxa/Mcl-1 balance determines sensitivity to ABT-737 in CD40-stimulated CLL cells. These data provide a rationale to investigate the combination of drugs which enhance the Noxa/Mcl-1 balance with ABT-737 to eradicate CLL in chemoresistant niches.

References

YearCitations

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