Publication | Open Access
The Clinical Isolate Pseudomonas aeruginosa MMA83 Carries Two Copies of the <i>bla</i> <sub>NDM-1</sub> Gene in a Novel Genetic Context
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Citations
12
References
2013
Year
Microbial PathogensGeneticsBacteriologyGenomicsBacterial PathogensNovel Genetic ContextAntimicrobial ResistancePseudomonas Aeruginosa Mma83Virulence FactorMolecular MicrobiologyClinical MicrobiologyGenetic ContextBlandm-1 GeneGram-negative BacteriologyAntimicrobial Resistance GenePathogenesisGenome SequencingMicrobiologyMedicineMicrobial Genetics
The genetic context of the blaNDM-1 gene in the genome of Pseudomonas aeruginosa MMA83 was investigated. Sequencing of the cosmid selected for the blaNDM-1 gene revealed the presence of two blaNDM-1 copies in the genome of P. aeruginosa MMA83 in a unique genetic environment. Additionally, mating assays, DNA-DNA hybridization, and an S1 nuclease assay strongly suggest that the blaNDM-1 gene in P. aeruginosa MMA83 is chromosome borne.
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