Genes & Development · 2005 · 70 citations · 36 references
Life SciencesDevelopmental BiologyMolecular BiologyCell SignalingDevelopmental GeneticsSignal TransductionDevelopmental Cell SignalingDevelopmental Signaling PathwaysMorphogen SignalingSignal Transduction PathwaysWnt SignalingCanonical Beta-catenin SignalingCanonical Wnt Beta-catenin PathwayCanonical Wnt PathwayCanonical Wnt SignalingPrimary CellsWnt In DevelopmentWnt Signal TransductionWnt Signaling Disruption
Wnt-signal transduction through beta-catenin is thought to require the inhibition of GSK3 by Frat/GBP. To investigate the role of Frat in mammalian development, we have generated mice with targeted mutations in all three murine Frat homologs. We show that Frat is normally expressed at sites of active Wnt signaling. Surprisingly, Frat-deficient mice do not display gross abnormalities. Moreover, canonical Wnt signaling in primary cells is unaffected by the loss of Frat. These studies show that Frat is not an essential component of the canonical Wnt pathway in higher organisms, despite the strict requirement of Frat/GBP for maternal Wnt signaling in Xenopus.
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A role for Wnt signalling in self-renewal of haematopoietic stem cells
Tannishtha Reya, Andrew W. Duncan, Laurie Ailles et al. · Nature · 2003 · 2.1K citations