Concepedia

A Pharmacophore for Human Pregnane X Receptor Ligands

Sean Ekins, Jon A. Erickson

Drug Metabolism and Disposition · 2002 · 152 citations · 15 references

DOI

Concepts

References

15

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

, , +14

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

Steven A. Kliewer, John T. Moore, Laura Wade et al. · Cell · 1998 · 1.5K citations · Full text

, , +16

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

Jeff L. Staudinger, Bryan Goodwin, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 2001 · 1.4K citations · Full text

, , +13

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

Linda B. Moore, Bryan Goodwin, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 2000 · 938 citations

, , +17

SXR, a novel steroid and xenobioticsensing nuclear receptor

Bruce Blumberg, Walid Sabbagh, Henry Juguilon et al. · Genes & Development · 1998 · 920 citations · Full text

, , +17