Topoisomerase IIα maintains genomic stability through decatenation G2 checkpoint signaling

A Topoisomerase IIß-Mediated dsDNA Break Required for Regulated Transcription

Bong‐Gun Ju, Victoria V. Lunyak, Valentina Perissi et al. · Science · 2006 · 833 citations

Histone Modifications, Molecular Biology, Multiple Enzymatic Activities +17

Topoisomerase IIβ–Mediated DNA Double-Strand Breaks: Implications in Doxorubicin Cardiotoxicity and Prevention by Dexrazoxane

Yi Lisa Lyu, John E. Kerrigan, Chao‐Po Lin et al. · Cancer Research · 2007 · 598 citations

Differential expression of DNA topoisomerases I and II during the eukaryotic cell cycle.

Margarete M. S. Heck, Walter N. Hittelman, William C. Earnshaw · Proceedings of the National Academy of Sciences · 1988 · 419 citations

Molecular Biology, Cell Cycle, Epigenetics +20

Antitumor bisdioxopiperazines inhibit yeast DNAtopoisomerase II by trapping the enzyme in the form of a closed proteinclamp.

Joaquím Roca, Ryoji Ishida, James M. Berger et al. · Proceedings of the National Academy of Sciences · 1994 · 351 citations · Full text

Molecular Biology, Antimicrobial Chemotherapy, Type Ii Dna +18

A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells

C. Stephen Downes, Duncan J. Clarke, Ann M. Mullinger et al. · Nature · 1994 · 323 citations

Genome Instability, Cell Regulation, Cell Division +5