A Highly Conserved Glycine within Linker I and the Extreme C Terminus of G Protein α Subunits Interact Cooperatively in Switching G Protein-Coupled Receptor-to-Effector Specificity

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

Philippe Samama, Susanna Cotecchia, Tommaso Costa et al. · Journal of Biological Chemistry · 1993 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

David E. Coleman, Albert M. Berghuis, E Lee et al. · Science · 1994 · 832 citations

Life Sciences, Biochemistry, Molecular Biology +17

Substitution of three amino acids switches receptor specificity of Gqα to that of Giα

Bruce R. Conklin, Zvi Farfel, Kevin D. Lustig et al. · Nature · 1993 · 736 citations

Life Sciences, Biochemistry, Molecular Biology +12

Molecular characterization of the melanin-concentrating-hormone receptor

Yumiko Saito, Hans‐Peter Nothacker, Zhiwei Wang et al. · Nature · 1999 · 545 citations

Life Sciences, Biochemistry, Molecular Biology +14

Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha.

Philip Wedegaertner, David H. Chu, Paul T. Wilson et al. · Journal of Biological Chemistry · 1993 · 299 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13