The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site

Katrin de Graaf, Hanna Czajkowska, Sabine Rottmann, Len C. Packman, Richard Lilischkis, Bernhard Lüscher, Walter Becker

BMC Biochemistry · 2006 · 104 citations · 30 references

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Abstract

The present data show that the splicing factor SF3b1 is a substrate of the protein kinase DYRK1A and suggest that DYRK1A may be involved in the regulation of pre mRNA-splicing.

References

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