<i>In vivo</i> isotopically labeled atherosclerotic aorta plaques in ApoE KO mice and molecular profiling by matrix‐assisted laser desorption/ionization mass spectrometric imaging

Abstract

The ability to couple stable isotope based protocols with MALDI-MSI enables a novel strategy to characterize the effects of therapeutic treatments on atherosclerotic plaque formation, regression and potential remodeling of the complex lipid components with high chemical specificity and spatiotemporal information.