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Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy

Urea OptimizationBiochemistryMedicineDiabetesType 2Protein X-ray CrystallographyGlycogen Phosphorylase InhibitorsPharmacologyCarbohydrate-protein InteractionDrug DiscoveryGlycosylation