A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib)

Edgar R. Wood, Anne T. Truesdale, Octerloney B. McDonald, +11

Cancer Research

Crystal StructureMolecular BiologyCell GrowthTumor BiologyDrug Effect +18

Combinations of BRAF, MEK, and PI3K/mTOR Inhibitors Overcome Acquired Resistance to the BRAF Inhibitor GSK2118436 Dabrafenib, Mediated by <i>NRAS</i> or <i>MEK</i> Mutations

James Greger, Stephen D. Eastman, Vivian Zhang, +7

Molecular Cancer Therapeutics

Oxindole-Based Inhibitors of Cyclin-Dependent Kinase 2 (CDK2):  Design, Synthesis, Enzymatic Activities, and X-ray Crystallographic Analysis

H. Neal Bramson, J. Corona, Stephen T. Davis, +18

Journal of Medicinal Chemistry

Oxindole-based InhibitorsOxindole-based CompoundsLigand DockingCell CycleHeterocycle Chemistry +14

Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors

Tara Rheault, John Stellwagen, George M. Adjabeng, +15

ACS Medicinal Chemistry Letters

B-raf-driven TumorsAntitumor ActivityHyperactive SignalingTumor BiologyMedicinal Chemistry +14

Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

Stephen T. Davis, Bill Benson, H. Neal Bramson, +23

Science

Cdk InhibitorsChemoprevention StrategyHair LossMedicinePharmacology +9

Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series

Kimberly G. Petrov, Yuemei Zhang, Malcolm Carter, +9

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetBiochemistryNatural SciencesMedicine +9

6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases

Edgar R. Wood, Lisa M. Shewchuk, Byron Ellis, +22

Proceedings of the National Academy of Sciences

Combinatorial ChemistryMedicinal ChemistryBiochemistryCovalent BondMedicine +11

<i>N</i>-Phenyl-4-pyrazolo[1,5-<i>b</i>]pyridazin-3-ylpyrimidin-2-amines as Potent and Selective Inhibitors of Glycogen Synthase Kinase 3 with Good Cellular Efficacy

Francis X. Tavares, Joyce A. Boucheron, Scott H. Dickerson, +5

Journal of Medicinal Chemistry

Cellular PharmacologySelective InhibitorsPharmaceutical ChemistryInsulin SignalingMolecular Pharmacology +16

Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors

Tara Rheault, Thomas R. Caferro, Scott H. Dickerson, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacotherapyAnti-cancer AgentDrug Development +3

Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors

Andrew J. Peat, Joyce A. Boucheron, Scott H. Dickerson, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineNovel Pyrazolopyrimidine DerivativesPharmacological AgentPharmacotherapy +4