Synthesis and activity of small molecule GPR40 agonists

Dulce Garrido, David F. Corbett, Kate A. Dwornik, +7

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyG Protein-coupled ReceptorMedicineFunctional SelectivityPharmacology +2

Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors

Andrew J. Peat, Joyce A. Boucheron, Scott H. Dickerson, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineNovel Pyrazolopyrimidine DerivativesPharmacological AgentPharmacotherapy +4

Rational Design of Potent Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase

Pek Y. Chong, Paul R. Sebahar, Michael Youngman, +10

Journal of Medicinal Chemistry

Molecular BiologyNew SeriesImidazole-amide Biarylether ScaffoldAntiviral DrugChemical Biology +15

Novel GSK-3 inhibitors with improved cellular activity

Andrew J. Peat, Dulce Garrido, Joyce A. Boucheron, +5

Bioorganic & Medicinal Chemistry Letters

MedicineReceptor Tyrosine KinaseCellular PharmacologyNovel Gsk-3 InhibitorsAnti-cancer Agent +4

Imidazo[1,2- <i>a</i> ]pyridines That Directly Interact with Hepatitis C NS4B: Initial Preclinical Characterization

J. Brad Shotwell, Subramanian Baskaran, Pek Y. Chong, +18

ACS Medicinal Chemistry Letters

The discovery and optimization of pyrimidinone-containing MCH R1 antagonists

Donald L. Hertzog, Kamal Albarazanji, Eric C. Bigham, +15

Bioorganic & Medicinal Chemistry Letters

MedicineRational Drug DesignMechanism Of ActionChemical BiologyPharmacology +1

Synthesis and evaluation of novel heterocyclic inhibitors of GSK-3

Terrence L. Smalley, Andrew J. Peat, Joyce A. Boucheron, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacological AgentNovel Heterocyclic InhibitorsPharmacotherapy +4

Design and synthesis of spirocyclic compounds as HCV replication inhibitors by targeting viral NS4B protein

Vincent W.‐F. Tai, Dulce Garrido, Daniel J. Price, +8

Bioorganic & Medicinal Chemistry Letters

Synthetic VirologyMedicineDrug DiscoveryAntiviral Drug DevelopmentAntiviral Therapy +8

6-(4-Chlorophenyl)-3-substituted-thieno[3,2-<i>d</i>]pyrimidin-4(3<i>H</i>)-one-Based Melanin-Concentrating Hormone Receptor 1 Antagonist

Francis X. Tavares, Kamal Albarazanji, Michael J. Bishop, +14

Journal of Medicinal Chemistry

ObesityMolecular PharmacologyMetabolic SyndromeMch Receptor 1Energy Homeostasis +13

Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy

Stephen A. Thomson, Pierette Banker, D. Mark Bickett, +14

Bioorganic & Medicinal Chemistry Letters

Urea OptimizationBiochemistryMedicineDiabetesType 2 +6