Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: is there a common mechanism?

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

Marisol Corral‐Debrinski, Terzah M. Horton, Marie T. Lott et al. · Nature Genetics · 1992 · 886 citations

Life Sciences, Genetics, Neuroscience +16

Somatic mutations of the mitochondrial genome in human colorectal tumours

Kornélia Polyák, Yunbo Li, Hong Zhu et al. · Nature Genetics · 1998 · 838 citations

Medicine, Genetics, Oncology +16

Detection of a specific mitochondrial DNA deletion in tissues of older humans

Gino Cortopassi, Norman Arnheim · Nucleic Acids Research · 1990 · 792 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +7

Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA

Kazuto Nakada, Kimiko Inoue, Tomoko Ono et al. · Nature Medicine · 2001 · 422 citations

Life Sciences, Genetics, Molecular Genetics +12

The epidemiology of pathogenic mitochondrial DNA mutations

Patrick F. Chinnery, T. M. Wardell, Laurence A. Bindoff et al. · Annals of Neurology · 2000 · 395 citations

Life Sciences, Genetics, Neurology +10