Concepedia

Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activation

Yingchun Li, Xiujuan Qu, Jinglei Qu, Ye Zhang, Jing Liu, Yuee Teng, Xuejun Hu, Kezuo Hou, Yunpeng Liu

Cancer Letters · 2009 · 82 citations · 31 references

DOI

Concepts

References

31

Surfing the p53 network

Bert Vogelstein, David P. Lane, Arnold J. Levine · Nature · 2000 · 6.6K citations

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In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

G-Q Chen, Jing Zhu, XG Shi et al. · Blood · 1996 · 852 citations · Full text

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Akt Enhances Mdm2-mediated Ubiquitination and Degradation of p53

Yoko Ogawara, Shohei Kishishita, Toshiyuki Obata et al. · Journal of Biological Chemistry · 2002 · 611 citations · Full text

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Stabilization of Mdm2 via Decreased Ubiquitination Is Mediated by Protein Kinase B/Akt-dependent Phosphorylation

Jianhua Feng, Rastislav Tamaskovic, Zhongzhou Yang et al. · Journal of Biological Chemistry · 2004 · 290 citations · Full text

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The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway.

Martin Sattler, Ravi Salgia, Keiko Okuda et al. · PubMed · 1996 · 258 citations

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