G-Q Chen

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

G-Q Chen, Jing Zhu, XG Shi et al. · Blood · 1996 · 852 citations · Full text

Life Sciences, Cell Biology, Oncology +16

Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1α

Yijun Huang, K-M Du, Z-H Xue et al. · Leukemia · 2003 · 104 citations · Full text

Life Sciences, Cancer Biology, Cell Biology +16

HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation

Ming He, Q-Q Yin, Juan Tang et al. · Cell Death and Differentiation · 2012 · 93 citations

Medicine, Molecular Biology, Oncology +14

Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1α that augments transcriptional activity of CCAAT/enhancer-binding protein-α

Yuheng Jiang, Z-H Xue, W-Z Shen et al. · Leukemia · 2005 · 83 citations

Medicine, Cancer Biology, Oncology +14

Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation

Qian Zhao, Jianguo Tao, Qian Zhu et al. · Leukemia · 2003 · 78 citations

Life Sciences, Cell Biology, Molecular Biology +11