Evaluation of Hepatic Disposition of Paroxetine Using Sandwich-Cultured Rat and Human Hepatocytes

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.

Y. Naritomi, Shigeyuki Terashita, Sumihisa Kimura et al. · PubMed · 2001 · 317 citations

Physiologically-based Pharmacokinetic Modeling, Cytochrome P450 Metabolism, Bioanalysis +21

Formation of extensive canalicular networks by rat hepatocytes cultured in collagen-sandwich configuration

Edward L. LeCluyse, Kenneth L. Audus, Jerome Hochman · American Journal of Physiology-Cell Physiology · 1994 · 260 citations

Tissue Engineering, Rat Primary Hepatocytes, Sandwich Configuration +16

Correlation of Biliary Excretion in Sandwich-Cultured Rat Hepatocytes and In Vivo in Rats

Xingrong Liu, Jack P. Chism, Edward L. LeCluyse et al. · Drug Metabolism and Disposition · 1999 · 228 citations

Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration

Xingrong Liu, Edward L. LeCluyse, Kenneth R. Brouwer et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 1999 · 224 citations

Sandwich Configuration, Cell Culture, Biliary Excretion +22