Concepedia

Genistein Downregulates SREBP-1 Regulated Gene Expression by Inhibiting Site-1 Protease Expression in HepG2 Cells

Eui Seok Shin, Hyoung Ho Lee, Si Young Cho, Hyun Woo Park, Sang Jun Lee, Tae Ryong Lee

Journal of Nutrition · 2007 · 70 citations · 27 references

DOI

Concepts

References

27

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Jay D. Horton, Joseph L. Goldstein, Michael S. Brown · Journal of Clinical Investigation · 2002 · 4K citations · Full text

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ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

Jin Ye, Robert B. Rawson, Ryutaro Komuro et al. · Molecular Cell · 2000 · 1.8K citations · Full text

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Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

Jay D. Horton, Iichiro Shimomura, Matthew Brown et al. · Journal of Clinical Investigation · 1998 · 707 citations · Full text

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Soybean Isoflavones Improve Cardiovascular Risk Factors without Affecting the Reproductive System of Peripubertal Rhesus Monkeys

Mary S. Anthony, Thomas B. Clarkson, Claude L. Hughes et al. · Journal of Nutrition · 1996 · 539 citations

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Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

Hitoshi Shimano, Iichiro Shimomura, Robert E. Hammer et al. · Journal of Clinical Investigation · 1997 · 446 citations · Full text

, , +14