Cold Spring Harbor Symposia on Quantitative Biology · 1978 · 30 citations · 0 references
Life SciencesGeneticsMolecular GeneticsChromatin BiologyChromatin StructureGenome OrganizationChromatinChromatin ArchitectureChromosome ArchitectureChromosome BiologyChromosome StructureGenome ArchitectureChromatin Dna ArchitectureChromatin OrganizationChromosome OrganizationDna Genome OrganizationGene ArchitectureGene Regulation By Chromatin Structure
In recent years considerable attention has been directed to questions concerning the structure and function of elementary genetic units in higher organisms. Most of this effort is focused upon studies of whole genome DNA, RNA, and chromatin. Eventually, resolution of these issues will require analysis at the level of specific genetic units, with DNA genetically marked in order to permit identification of structural and regulatory components and to relate these components to their specific functions. Such an approach remains for the future. For some years, major emphasis in this laboratory has been directed toward the development of an experimental system for just such investigation in Drosophila melanogaster. This paper summarizes our recent progress in this work.