Ligand Bridging of the DNA Holliday Junction: Molecular Recognition of a Stacked‐X Four‐Way Junction by a Small Molecule

Abstract

Planning a Holliday: A new mode of binding to a stacked-X, four-way Holliday junction is described in which a chromophore molecule binds across the center of the junction and two adenine residues are replaced by the acridine chromophores at either side of the crossover. This binding mode is specific for the Holliday junction and does not cause unwinding of the DNA helices. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z603760_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.