Recombinant <scp>DNA</scp> immunotherapy ameliorate established airway allergy in a <scp>IL</scp>‐10 dependent pathway

Abstract

Our findings clearly show that immunotherapy with DNA encoding Hsp65 can attenuate an established Th2 allergic inflammation through an IL-10-dependent mechanism; moreover, the migration of allergen- and Hsp65-specific cells to the allergic sites exerts a fundamental role. This work represents a novel contribution to the understanding of immune regulation by Hsp65 in allergic diseases.