Concepedia

Interplay between VHL/HIF1α and Wnt/β-catenin pathways during colorectal tumorigenesis

Rachel H. Giles, Martijn P. Lolkema, Cristel M.J.T. Snijckers, Mirjam E. Belderbos, Petra van der Groep, Dorus A. Mans, Moniek van Beest, Mascha van Noort, Roel Goldschmeding, P. J. van Diest,

Oncogene · 2005 · 108 citations · 30 references

DOI

Concepts

References

30

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

, , +17

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

, , +16

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC <sup>−/−</sup> Colon Carcinoma

Vladimír Kořínek, Nick Barker, Patrice J. Morin et al. · Science · 1997 · 3.3K citations

, , +17

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Peter Carmeliet, Yuval Dor, Jean-Marc Herbert et al. · Nature · 1998 · 2.5K citations

, , +16

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

Marc van de Wetering, Elena Sancho, Cornelis L. Verweij et al. · Cell · 2002 · 2K citations · Full text

, , +16