Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T‐cell activation

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

Stefan Feske, Yousang Gwack, Murali Prakriya et al. · Nature · 2006 · 2.3K citations

Life Sciences, Immunology, Molecular Biology +10

Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca ²⁺ Responses

Rosario Rizzuto, Paolo Pinton, Walter Carrington et al. · Science · 1998 · 2.2K citations

Life Sciences, Biophysics, Cell Biology +17

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

Joshua M. Baughman, Fabiana Perocchi, Hany S. Girgis et al. · Nature · 2011 · 1.9K citations · Full text

Life Sciences, Genetics, Molecular Biology +15

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

Diego De Stefani, Anna Raffaello, Enrico Teardo et al. · Nature · 2011 · 1.9K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Orai1 is an essential pore subunit of the CRAC channel

Murali Prakriya, Stefan Feske, Yousang Gwack et al. · Nature · 2006 · 1.3K citations

Natural Sciences, Biochemistry, Molecular Biology +13