T cell activation requires mitochondrial translocation to the immunological synapse

Ariel Quintana, Christian Schwindling, Anna S. Wenning, +4

Proceedings of the National Academy of Sciences

Th Cell ActivationSignal TransductionMitochondrial FunctionMitochondrial TranslocationTh Cells +13

Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T‐cell activation

Ariel Quintana, Mathias Pasche, Christian Junker, +10

The EMBO Journal

Identification of the Minimal Protein Domain Required for Priming Activity of Munc13-1

David R. Stevens, Zheng-Xing Wu, Ulf Matti, +6

Current Biology

Priming ActivityProtein FunctionNatural SciencesSignal RecognitionMolecular Biology +4

Calcium regulates exocytosis at the level of single vesicles

Ute Becherer, Tobias Moser, Walter Stühmer, +1

Nature Neuroscience

Molecular PhysiologyEndocytic PathwayExtracellular MicrovesiclesSingle VesiclesIntracellular Trafficking +4

CAPS1 Regulates Catecholamine Loading of Large Dense-Core Vesicles

Dina Speidel, Cathrin E. Bruederle, Carsten Enk, +11

Neuron

Large Dense-core VesiclesCytoskeletonProtein TransportIntracellular TraffickingCellular Biochemistry +5

Primed Vesicles Can Be Distinguished from Docked Vesicles by Analyzing Their Mobility

Shahira Nofal, Ute Becherer, Detlef Hof, +2

Journal of Neuroscience

VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity

Misty Marshall, Varsha Pattu, Mahantappa Halimani, +8

The Journal of Cell Biology

Directed ReleaseImmune RegulationImmunologyCell DeathPathology +16

Synaptobrevin2 is the v-SNARE required for cytotoxic T-lymphocyte lytic granule fusion

Ulf Matti, Varsha Pattu, Mahantappa Halimani, +13

Nature Communications

Cell TraffickingImmunologyImmunodominanceAntigen ProcessingAutoimmunity +2

Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes

Hsin‐Fang Chang, Claudia Schirra, Momchil Ninov, +12

Nature Communications

Docking of Lytic Granules at the Immunological Synapse in Human CTL Requires Vti1b-Dependent Pairing with CD3 Endosomes

Bin Qu, Varsha Pattu, Christian Junker, +11

The Journal of Immunology

ImmunologyCell DeathMolecular BiologyAntigen ProcessingCytoskeleton +19