<i>HLA-DQA1</i> * <i>02:01</i> Is a Major Risk Factor for Lapatinib-Induced Hepatotoxicity in Women With Advanced Breast Cancer - Concepedia

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<i>HLA-DQA1</i> * <i>02:01</i> Is a Major Risk Factor for Lapatinib-Induced Hepatotoxicity in Women With Advanced Breast Cancer

274

Citations

23

References

2011

Year

Colin F. Spraggs, L. R. Budde, Linda P. Briley, Nan Bing, Charles Cox, Karen S. King, John C. Whittaker, Vincent Mooser, A. Preston, Steven H. Stein,

Journal of Clinical Oncology

Abstract

These results support a role for immune mechanisms in lapatinib-induced hepatotoxicity. Further work is required to determine whether testing for DQA1*02:01 allele carriage is clinically useful in managing liver safety risk during lapatinib treatment.

References

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