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Early G1 Cyclin-Dependent Kinases as Prognostic Markers and Potential Therapeutic Targets in Esophageal Adenocarcinoma

DOI

54

Citations

31

References

2011

Year

Amin Ismail, Santhoshi Bandla, Marie Réveiller, Liana Toia, Zhongren Zhou, William E. Gooding, Irina Kalatskaya, Lincoln Stein, Mary D’Souza, Virginia R. Litle,
Clinical Cancer Research

Abstract

We suggest that CDK6 is the driver of 7q21 amplification and that both CDK4 and CDK6 are prognostic markers and bona fide oncogenes in EAC. Targeting these molecules may constitute a viable new therapy for this disease.

References

YearCitations

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