Concepedia

Sequence-specific Gene Knockdown

Sequence-Specific Gene Knockdown is a molecular biology technique that selectively reduces the expression of a targeted gene by exploiting nucleotide complementarity to degrade or inhibit its mRNA transcript.

95

Publications

12.4K

Citations

464

Authors

156

Institutions

Publications per year

2017–2026

12

Parents

Publications

95

RNA interference is mediated by 21- and 22-nucleotide RNAs

Sayda M. Elbashir, Winfried Lendeckel, Thomas Tuschl · Genes & Development · 2001 · 3.3K citations · Full text

, , +15

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

Patrick J. Paddison, Amy A. Caudy, Emily Bernstein et al. · Genes & Development · 2002 · 1.6K citations · Full text

, , +13

p53 Activation by Knockdown Technologies

Mara E. Robu, Jon D. Larson, Aidas Nasevicius et al. · PLoS Genetics · 2007 · 1K citations · Full text

, , +16

Sequence-Specific Knockdown of EWS-FLI1 by Targeted, Nonviral Delivery of Small Interfering RNA Inhibits Tumor Growth in a Murine Model of Metastatic Ewing's Sarcoma

Siwen Hu‐Lieskovan, Jeremy D. Heidel, Derek W. Bartlett et al. · Cancer Research · 2005 · 565 citations

, , +17

Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells.

Hao Wu, William N. Hait, Jin-Ming Yang · PubMed · 2003 · 292 citations

, , +15

1–5 of 95

Authors

464

  1. OM
    Osam Mazda

    Kyoto Prefectural University of Medicine, Japan

    2 publications · 40 citations

    2

    h-index

  2. RM
    Rainer Maier

    Novartis (Switzerland), Switzerland

    2 publications · 235 citations

    2

    h-index

  3. QP
    Qiuwei Pan

    Erasmus MC, Netherlands

    2 publications · 196 citations

    2

    h-index

  4. YA
    Yuji Arai

    Kyoto Prefectural University of Medicine, Japan

    2 publications · 40 citations

    2

    h-index

  5. AN
    Aidas Nasevicius

    University of Minnesota, United States

    2 publications · 1K citations

    2

    h-index

1–5 of 464

Institutions

156

  1. Cold Spring Harbor Laboratory

    Cold Spring Harbor, United States

    4 h-index

    12 publications

    8.5K citations

  2. Kyoto Prefectural University of Medicine

    Kyoto, Japan

    3 h-index

    25 publications

    497 citations

  3. Rutgers, The State University of New Jersey

    New Brunswick, United States

    2 h-index

    5 publications

    230 citations

  4. Commonwealth Scientific and Industrial Research Organisation

    Canberra, Australia

    2 h-index

    12 publications

    486 citations

  5. Kyushu University

    Fukuoka, Japan

    2 h-index

    7 publications

    382 citations

  6. Kyoto University Hospital

    Kyoto, Japan

    2 h-index

    4 publications

    62 citations

  7. UConn Health

    Farmington, United States

    2 h-index

    4 publications

    329 citations

  8. Australian Centre for Disease Preparedness

    Geelong, Australia

    2 h-index

    10 publications

    426 citations

1–8 of 156

Venues

  1. Bioconjugate Chemistry

    5 publications · 195 citations

    5

    h-index

  2. PubMed

    Repository · 4 publications · 679 citations

    4

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 483 citations

    4

    h-index

  4. Hepatology

    3 publications · 432 citations

    3

    h-index

  5. Oligonucleotides

    3 publications · 131 citations

    3

    h-index

1–5