Identification of a Cranberry Juice Product that Inhibits Enteric CYP3A-Mediated First-Pass Metabolism in Humans

THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”

Mary F. Paine, Heather L. Hart, Shana S. Ludington et al. · Drug Metabolism and Disposition · 2006 · 874 citations

Medicine, Biochemistry, Pharmacology +12

Characterization of Interintestinal and Intraintestinal Variations in Human CYP3A-Dependent Metabolism

Mary F. Paine, Mehraneh Khalighi, Jeannine M. Fisher et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 792 citations

Medicine, Pharmacokinetics, Pharmacology +17

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*

Kenneth E. Thummel, Diarmuid O’Shea, Mary F. Paine et al. · Clinical Pharmacology & Therapeutics · 1996 · 619 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Interaction of citrus juices with felodipine and nifedipine

Dg Bailey, J. David Spence, Claudio Munoz et al. · The Lancet · 1991 · 592 citations

Medicine, Pharmacology, Pharmacotherapy +5

Reduction of Bacteriuria and Pyuria After Ingestion of Cranberry Juice

Jerry Avorn · JAMA · 1994 · 541 citations

Life Sciences, Infectious Diseases, Nutrition +4