SREBP-1c overexpression induces triglycerides accumulation through increasing lipid synthesis and decreasing lipid oxidation and VLDL assembly in bovine hepatocytes

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Jay D. Horton, Joseph L. Goldstein, Michael S. Brown · Journal of Clinical Investigation · 2002 · 4K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

Li Yu, Shanqin Xu, Maria M. Mihaylova et al. · Cell Metabolism · 2011 · 1.7K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

Jay D. Horton, Nila Shah, Janet A. Warrington et al. · Proceedings of the National Academy of Sciences · 2003 · 1.4K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice

Iichiro Shimomura, Morihiro Matsuda, Robert E. Hammer et al. · Molecular Cell · 2000 · 832 citations

Life Sciences, Biochemistry, Endocrinology +16

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

Iichiro Shimomura, Yuriy K. Bashmakov, Shinji Ikemoto et al. · Proceedings of the National Academy of Sciences · 1999 · 791 citations · Full text

Life Sciences, Endocrinology, Molecular Biology +12