Concepedia

Skewed distribution of Th17 lymphocytes in patients with Wegener's granulomatosis in remission

Wayel H. Abdulahad, Coen A. Stegeman, Pieter C. Limburg, Cees G. M. Kallenberg

Arthritis & Rheumatism · 2008 · 176 citations · 46 references

DOI

Abstract

A skewed Th17 response found in ANCA-positive WG patients following stimulation with the autoantigen PR3 suggests that IL-17 is involved in disease pathogenesis and could constitute a new therapeutic target.

References

46

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Estelle Bettelli, Yijun Carrier, Wenda Gao et al. · Nature · 2006 · 6.8K citations

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Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Laurie E. Harrington, Robin D. Hatton, Paul R. Mangan et al. · Nature Immunology · 2005 · 4.6K citations

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Heon Park, Zhaoxia Li, Xuexian O. Yang et al. · Nature Immunology · 2005 · 4.2K citations · Full text

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TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Marc Veldhoen, Richard J. Hocking, Christopher J. Atkins et al. · Immunity · 2006 · 3.6K citations · Full text

, , +9

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

J. Daniel, Jonathan Sherlock, Yi Chen et al. · Nature · 2003 · 2.9K citations

, , +14