β-Cryptoxanthin Synergistically Enhances the Antitumoral Activity of Oxaliplatin through Δ <i>NP73</i> Negative Regulation in Colon Cancer

Abstract

We propose a putative novel therapeutic strategy for the treatment of colon cancer based on the combination of β-cryptoxanthin and oxaliplatin. The combined regimen produced more benefit than either individual modality without increasing side effects. In addition, the concentration-limiting toxicity of oxaliplatin is reduced in the presence of the carotenoid.