Organic & Biomolecular Chemistry · 2013 · 97 citations · 11 references
Life SciencesBotanyPlant BiologyMetabolismPlant BiochemistryPlant Molecular BiologyAromatic PlantsCytochrome P450 EnzymesCytochrome P450-mediated MetabolismPlant Natural Product BiosynthesisSteroid BiosynthesisTerpenoid BiosynthesisAromatic Compound BiosynthesisAromatic HydroxylationCytochrome P450 Enzymes In Phenylpropanoid MetabolismCytochrome P450-mediated Terpenoid OxidationDiterpene BiosynthesisMonoterpene BiosynthesisPlant Aroma BiosynthesisPlant Phenolics
Miltiradiene (1) is the precursor of phenolic diterpenoids such as ferruginol (2), requiring aromatization and hydroxylation. While this has been attributed to a single cytochrome P450 (CYP76AH1), characterization of the rosemary ortholog CYP76AH4 led to the discovery that these CYPs simply hydroxylate the facilely oxidized aromatic intermediate abietatriene (3).
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