Concepedia

Publication | Open Access

Rap1-Rac1 Circuits Potentiate Platelet Activation

DOIFull Paper Access

77

Citations

41

References

2011

Year

Lucia Stefanini, Yacine Boulaftali, Timothy Daniel Ouellette, Michael Holinstat, Laurent Désiré, Bertrand Leblond, Patrick André, Pamela B. Conley, Wolfgang Bergmeier
Arteriosclerosis Thrombosis and Vascular Biology

Abstract

We demonstrate important crosstalk between Rap1 and Rac1 downstream of GPVI. Whereas Rap1 signaling directly controls sustained Rac1 activation, Rac1 affects CalDAG-GEFI- and P2Y12-dependent Rap1 activation via its role in calcium mobilization and granule/ADP release, respectively.

References

YearCitations

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